A STUDY OF POTENTIAL HISTIDINE DECARBOXYLASE INHIBITORS
نویسندگان
چکیده
منابع مشابه
MOLECULAR MODELING AND NMR STUDY OF HISTDINIE AND ITS ANALOGUES AS , PYRIDOXAL 5 '-PHOSPHATE DEPENDENT HISTIDINE DECARBOXYLASE INHIBITORS
Molecular modeling analysis of charge density and heat of fornation by PM3 method as well as C, H NMR and 2D-NMR measurements of histidine (substrate) and some of its derivatives as histidine decarboxylase inhibitors were performed. It was established that the atom, usually nitrogen, which forms internal aldimine with pyridoxal5 -phosphate (PLP), (coenzyme), has negative and almost equal ...
متن کاملSeeking a Cure for Hay Fever: A Study of Inhibitors of the Histidine Decarboxylase Reaction
Objectives/Goals Human mast cells produce histidine decarboxylase, which catalyzes the histidine decarboxylation reaction, converting histidine to histamine. This reaction causes histamine to attach to receptors in the immune system, resulting in allergy symptoms. Current treatments for hay fever include antihistamines, a class of chemicals that prevent histamine from attaching to these recepto...
متن کاملA Rapid Histidine Decarboxylase Assay1
Histidine decarboxylase (EC 4.1.1.22) catalyzes the conversion of histidine to histamine. Because current assays for enzyme activity are time consuming and require additional enzymes or large amounts of tissue, a rapid radioisotopic assay was devised. Using commercially available radioactive histidine (without additional purification), the enzyme mediates the formation of histamine. The product...
متن کاملmolecular modeling and nmr study of histdinie and its analogues as , pyridoxal 5 '-phosphate dependent histidine decarboxylase inhibitors
molecular modeling analysis of charge density and heat of fornation by pm3 method as well as c, h nmr and 2d-nmr measurements of histidine (substrate) and some of its derivatives as histidine decarboxylase inhibitors were performed. it was established that the atom, usually nitrogen, which forms internal aldimine with pyridoxal5 -phosphate (plp), (coenzyme), has negative and almost equal charge...
متن کاملIn vitro study of proteolytic degradation of rat histidine decarboxylase.
Mammalian ornithine decarboxylase (ODC) is a very unstable protein which is degraded in an ATP-dependent manner by proteasome 26S, after making contact with the regulatory protein antizyme. PEST regions are sequences described as signals for protein degradation. The C-terminal PEST region of mammalian ODC is essential for its degradation by proteasome 26S. Mammalian histidine decarboxylase (HDC...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Pharmacology and Chemotherapy
سال: 1960
ISSN: 0366-0826
DOI: 10.1111/j.1476-5381.1960.tb00279.x